ORAL CANDIDIASIS : Etiology and pathogenesis, epidemiology, clinical findings, clinical manifestations, diagnosis, laboratory findings, management
1, Etiology and Pathogenesis C.albicans, C.tropicalis, and C.glabrata comprise together over 80% of the species isolated from human Candida infection. to invade the mucosal lining, the microorganisms must adhere to the epithelial surface; therefore, strains of candida with better adhesion potential are more pathogenic than strains with poorer adhesion. the yeasts penetration of the epithelial cells is facilitated by their production of lipases, and for the yeasts to remain within the epithelium, they must overcome constant desquamation of surface epithelial cells. There is an apparent association between oral candidiasis and the in uence of local and general predisposing factors. The local predisposing factors are able to promote growth of Candida or to affect the immune response of the oral mucosa. General predisposing factors are often related to the patient’s immune and endocrine status The immune status can be affected by drugs as well as a dis- ease, which suppresses the...